CBD is short for Cannabidiol and is the second most abundant constituent in Hemp. CBD is different to THC as it has no psychoactive effects, meaning it does not get you high. CBD is one of 144 known chemical substances known as cannabinoids, which are all found in the cannabis plant. CBD is the second most abundant compound in hemp, typically representing up to 40% of its extracts. The Cannabis plant exudes cannabinoids and terpenes on to its leaves and flowers in response to sunlight and pests. It is understood that humans have cultivated and consumed hemp food products for thousands of years, carrying their cannabis seeds with them over great distances.
The human Endo-Cannabinoid System (ECS) was discovered in 1992 and subsequent research has revealed a network of cell receptors designed to interact with cannabinoid molecules. Endocannabinoids are internal cannabinoid molecules that our bodies are supposed to produce, to trigger ECS receptors. It is thought that certain environmental factors may inhibit our production of our internal cannabinoid molecules. While the mechanisms are not well understood, CBD is thought to interact with a range of cell receptors, causing subsequent physiological responses.
CBD is short for Cannabidiol. Cannabidiol is the second most common cannabinoid present in the different varieties of Cannabis plants.
CBD is not a harmful substance and has been proven to have an extremely low risk profile. There are no records to date of any individual having an adverse reaction to CBD and it is tolerated well by the body.
Currently CBD Is legal in the U.K. if sold as a food supplement and produced from Cannabis Sativa L. (Hemp) and contains a maximum of 0.2% THC. You can rest assured that all Holistic Herb products are THC free!
NO! CBD is 100% non-psychoactive, this means that there are no changes in an individual’s perception, mood or consciousness having consumed CBD.
This is one of the most commonly asked questions surrounding CBD. Most genetic variations of Cannabis Sativa L. carry some amount of both THC (Tetrahydrocannabinol) and CBD (Cannabidiol), and therefore in a full spectrum natural plant extract, THC will be present.
However Holistic Herb products are manufactured using refined extracts, and as a result are THC free, meaning you don’t need to worry about THC consumption with Holistic Herb CBD products.
The one major and important difference between CBD and THC is that CBD (Cannabidiol) is entirely non-psychoactive, this means that there are no changes in an individual’s consciousness or perception of their environment having consumed CBD, as there is with THC consumption.
NO! All Holistic Herb CBD products are 0.000% THC free.
Holistic Herb’s unique formulation and encapsulation means that there is no need for our oil to be left under the tongue but would not do any harm if you did. With over 98% of the active CBD in the Holistic Herb product being fully absorbed into the bloodstream, you can be confident that our Total Bioavailability™ is helping to bring you a more efficient product and value for money.
No. Currently the majority of CBD sold in the UK is in the form of Food Supplements and therefore does not require a prescription.
You can now purchase Holistic Herb products here on our own website or alternatively all Holistic Herb products can be purchased from over 700 Holland & Barrett high street retail stores.
https://www.hollandandbarrett.com/shop/brands/holistic-herb/
Holistic Herb premium CBD oil has a two-year shelf life from the date of manufacture, and this is reflected in the Best Before date which is printed on both the bottle and the box.
It is recommended to store your CBD in a cool dark place to maintain optimum performance of the active ingredients.
Bioavailability is the proportion of a substance that enters into circulation when introduced into the body and is able to have an active effect. Holistic Herb products include technology that increases bioavailability, meaning there is a greater proportion of the CBD available to have an active effect in your body.
Holistic Herb’s uniquely micro-emulsified Premium CBD has vastly superior Total Bioavailability™, which means it is more efficient, entering the bloodstream faster and remaining there in higher quantities for longer after application.
Regular CBD products are not as efficiently absorbed and are not protected, and as a result they can lose as much as 95% of the active CBD through destruction by the digestive system on their way to the bloodstream. As a result, only a small fraction of active CBD from regular products makes it to the bloodstream.
It is actually scientifically unclear as to how CBD interacts with the body. It plays a role in increasing the body’s production of its own natural endocannabinoids and clears the cannabinoid receptor sites to enable increased uptake of these internally produced cannabinoids.
CB1 and CB2 receptors are G protein-coupled receptors that are found in the walls of the cells in various organs in our body.
These receptors form what has been termed the endocannabinoid system, which is a network that form a signalling pathways to impact a wide range of physiological processes.
CBD can have either a calming or an uplifting effect, depending on how your body interacts with the substance. Start with a low dose initially to understand how your own personal reaction to CBD and build up the dosage if required.
Cannabinoids are a type of organic compound produced by the cannabis plant and were named as such as they were thought to be unique to the plant. There are currently 144 known Cannabinoids found in the Cannabis plant, of which two are found in high quantities, THC and CBD. Other more prevalent compounds are CBC and CBG.
When consumed by humans, Cannabinoids interact with receptors found in the walls of cells in certain organs in our body.
Activation of these receptors seems to trigger chain reactions that alter chemical processes and neural signalling in humans.
CBD and hemp oil are made from different parts of the plant. Typically, hemp oils are made from pressing hemp seeds whilst CBD is extracted from hemp (Cannabis Sativa L.), flowers and leaves.
There are several ways to extract the valuable compounds from Hemp. The most common methods used by commercial producers are:
Liquid Solvents: Usually Butane, isopropyl alcohol, hexane or ethanol, they are passed through the plant matter to remove cannabinoid and flavours. They are then transferred to the liquid which is in turn evaporated away to leave concentrated chemicals and flavours in oil form. There are however some concerns surrounding this extraction method as Liquid
Solvents can leave trace impurities.
CO2 Extraction: Utilizing a ‘Closed Loop Extractor’ this form of extraction is very gentle and is fast becoming the preferred extraction technique. CO2 can exist as a solid, liquid or gas this allows for variables in pressure and temperature to be manipulated to extract the compounds that you require and discard the ones you do not. Unlike extraction using Liquid Solvents there is minimal risk of contaminants.
Water Extraction: New techniques are emerging that retain more of the plant’s beneficial compounds. Cannabinoids and Terpenes are extremely temperature and pressure sensitive, therefore cold-water extraction enables the retention of a much greater proportion of these compounds through the extraction process, and therefore a better end product.
CBD should not impair your ability to drive. If you are taking CBD to assist in sleep or relaxation take care with application time and dosing.
CBD is not tested for in any drugs tests. As of January 2018 the World Anti- Doping agency removed CBD from the banned substances list.
CBD can be applied in multiple ways, depending on the purpose of use.
Sublingual application results in absorption through the many blood vessels under the tongue and around the mouth, which results in relatively high absorption.
Ingestion will generally have lower levels of absorption but will tend to have a slower onset and longer lasting effect.
Inhalation offers higher absorption rates, and is generally faster acting, but does not last as long.
Holistic Herb’s unique formulation and encapsulation means that there is no need for our oil to be left under the tongue but would not do any harm if you did. With over 98% of the active CBD in the Holistic Herb product being fully absorbed into the bloodstream, you can be confident that our Total Bioavailability™ is helping to bring you a more efficient product and value for money.
There is no ‘perfect’ or ‘optimal’ time to take CBD as every individual is different and many report differing effects. Some individuals report that CBD has an awakening effect for them and therefore take it in the morning, others whom CBD has this awakening effect prefer to take it at lunchtime or early afternoon when their energy levels may be reducing.
On the other hand, some individuals report that CBD has a relaxing effect and prefer to take it in the evening or before bed.
It may be best to see how CBD works for you and adjust the time you take CBD accordingly.
This varies significantly depending on the mode of application. Inhalation will result in CBD entering the blood stream within a matter of minutes.
Sublingual application may take a little longer.
Ingestion can take anywhere from 30 minutes to 2 hours depending on when you have eaten, how hydrated you are, and your metabolic rate.
CBD will behave differently depending on the mode of application, as well as for each individual, so the amount of time it takes to leave your system will vary.
Ingested CBD will remain in your system for longer, whereas inhaled CBD tends to be used up quicker. Sublingual application is somewhere between the two.
CBD does have a tendency to build up in your system, which is why it is important for each individual to find the right daily dose for themselves.
The only robust clinical evidence for CBD treating a medical condition is for Dravets Syndrome, a rare and severe form of epilepsy. While there are lots of animal trials showing potential benefits for CBD treatment in humans, none of these have been clinically verified.
Anecdotally CBD does seem to offer benefit in helping people cope with stress and anxiety, improving sleep, and relaxation.
CBD has anecdotally been shown to be beneficial for relieving stress, and aiding relaxation and sleep. There are also anecdotal reports and trials on CBD treating conditions such as anxiety, inflammation, and pain, but these reports are not supported by full clinical trials and should be treated with CBD without consulting your GP or specialist physician.
It is best to check with your GP or specialist physician if you are on long term medication for a chronic condition. CBD does interact with the CP450 enzymes in the liver that are responsible for activating most ingested medications.
Each person must find their own daily dose to suit their own needs. Start low and build it up as required. If you are taking long term medication, please check with your GP or specialist physician for any potential interactions that may be problematic.
All different genetic varieties of cannabis (including hemp) produce a different Phyto complex (mix of active compounds driven by light) therefore there isn’t any difference in CBD itself, but a full spectrum oil from a cannabis variety may have a wider array of cannabinoids and terpenes, and therefore may be more effective for a wider range of people.
There is no indication that CBD effects appetite. While there is anecdotal evidence of CBD having a positive effect on dietary conditions such as diabetes, there are no clinical trials to support this.
There are no known side effects of CBD to date. We do recommend that you speak to your GP or Specialist physician if you are talking CBD alongside any other regular medication for a long-term condition as interactions may occur.
There aren’t any known cases of large doses of CBD producing negative effects on individuals. We advise you start with a low dose and build up slowly to find an effective daily dose that works for you.
GW Pharmaceuticals have achieved a Marketing Authorisation for a CBD based medicine to treat Dravets Syndrome, a rare and severe form of epilepsy. The clinical trial process for this authorisation will have included safety testing.
However, this product is produced under strictly controlled conditions, to the medical highest standards of safety and consistency.
No other CBD products have undergone this testing, and few are produced to GMP pharmaceutical standard.
Production of industrial hemp/cannabis is controlled under license by all governments globally. As a result, it is produced in small volumes relative to many other food-based plants. As volume of cultivation and production grows product prices are likely to decrease.
Our products contain a carrier oil that is a mix of Olive Oil and Coconut Oil, Emulsifier: Polysorbate 80 E433 as well as our unique encapsulation technology.
Each individual has a different biochemistry given their genetic makeup, height and weight, diet, level of exercise, work environment and living environment.
All of these factors affect the body’s biochemical mechanisms, therefore will affect how CBD interacts with it.
CBD is not known to have addictive qualities.
CBD is not known to reduce addictive behavioural tendencies.
It is not recommended to take CBD whilst pregnant as there is currently not enough research to determine the safety of taking CBD whilst pregnant, breastfeeding or planning to become pregnant.
It is not recommended to fly or travel internationally in the procession of CBD products as it may potentially be an illegal product in your destination country or territory. It is always best to err on the side of caution as many countries have very stringent controls and penalties for procession of Cannabis in any form.
CBD has been shown to be beneficial for many mammal pets, in similar ways to that for humans. As mammals we share similar physiological and biochemical systems, therefore it is natural that CBD will have similar benefits for animals.
The UK Veterinary medicines authority has recently announced that CBD will be classed as a medicine for animals, which underlines a clear indication of benefit for animals.
There are a large number of both animal and human trials studying the mechanisms and benefits of CBD. While these trials cover the potential treatment of a wide scope of conditions, there are not many full-scale clinical trials, therefore these indications are clearly just that for now.
GW pharmaceuticals have recently secured a marketing authorisation for a CBD based product called Epidiolex, for the treatment of Dravets Syndrome, a rare and severe form of epilepsy in children.
